Abstract |
The in vitro antitumor activities of 2,6-di-[2-(heteroaryl)vinyl] pyridines versus the standard National Cancer Institute 60 cell lines panel and of 2,6-di-[2-(heteroaryl)vinyl] pyridinium cations versus MCF7 ( human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. Antiproliferative effects in both series are particularly evident for MCF7 mammary adenocarcinoma cells. Multivariate analysis of DNA microarray data for responsive tumor cell lines suggest a mechanistic pathway involving polyamine biosynthesis and prolactin signal transduction.
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Authors | Vincenza Barresi, Daniele F Condorelli, Cosimo G Fortuna, Giuseppe Musumarra, Salvatore Scirè |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 10
Issue 9
Pg. 2899-904
(Sep 2002)
ISSN: 0968-0896 [Print] England |
PMID | 12110310
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Polyamines
- Pyridines
- Pyridinium Compounds
- Prolactin
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Topics |
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Female
- Gene Expression Profiling
- Humans
- Male
- Multivariate Analysis
- Oligonucleotide Array Sequence Analysis
- Polyamines
(metabolism)
- Prolactin
(metabolism)
- Pyridines
(chemical synthesis, pharmacology)
- Pyridinium Compounds
(chemical synthesis, pharmacology)
- Signal Transduction
- Structure-Activity Relationship
- Tumor Cells, Cultured
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