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Efficacy of induction chemoradiotherapy in thymic cancer: report of a successful case and review of the literature.

Abstract
Thymic cancer is a rare tumor, the optimal treatment of which remains controversial. The efficacy of induction therapy in thymic cancer is unclear. A 51-year-old man was diagnosed as having a poorly differentiated carcinoma of the thymus with lymph node metastasis (stage IVb according to the Masaoka staging system), through an echo-guided biopsy. The patient was administrered cisplatin (CDDP) combined with paclitaxel once per week for 4 weeks, under concurrent local radiation. Once a partial response was achieved, the residual tumor was completely resected, and bilateral mediastinal lymph nodes were dissected. Histopathological examination of the resected specimen showed no evidence of viable malignant cells. At present, 15 months after surgery, the patient is doing well and shows no signs of recurrence. This case demonstrates that induction chemoradiotherapy with CDDP and paclitaxel may be well tolerated and useful for patients with advanced thymic cancer.
AuthorsAtsushi Morio, Kazuki Nakahara, Yoshio Ohse, Minoru Tahara, Takeshi Goto, Kazuhiro Yakumaru, Tatheo Korenaga
JournalInternational journal of clinical oncology (Int J Clin Oncol) Vol. 7 Issue 3 Pg. 201-4 (Jun 2002) ISSN: 1341-9625 [Print] Japan
PMID12109524 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Paclitaxel
  • Cisplatin
Topics
  • Adenocarcinoma (drug therapy, radiotherapy, secondary)
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Cisplatin (administration & dosage)
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Paclitaxel (administration & dosage)
  • Radiography, Thoracic
  • Remission Induction
  • Thymus Neoplasms (drug therapy, pathology, radiotherapy)

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