Abstract | BACKGROUND: METHODS: AH-130 cells, a rat hepatoma cell line, were solidified and implanted into the liver of Donryu rats. Vascularity of the liver tumor was directly identified by in-vivo fluorescence microscopy from 0 to 60 min after the injection of 10 mg/kg AC-7700. To observe the antivascular effect of AC-7700, the vascular density of the tumor was measured and assessed as the ratio of preinjection to postinjection values. The antitumor effects were evaluated with histopathologic findings and analysis of animal survival. RESULTS: In-vivo microscopic observation showed that tumor perfusion diminished within 30 min after AC-7700 administration. Vascular density in the AC-7700 group was significantly less than that in the control group at 60 min ( AC-7700, 26.3 +/- 16.4%; control, 88.5 +/- 9.2%; P < 0.001). After AC-7700 injection, marked necrosis of tumor cells was observed histologically, and tumor area was decreased significantly ( AC-7700, 11.5 +/- 15.4 mm2; control, 43.5 +/- 18.3 mm2; P < 0.05). The survival rate (50%) of the AC-7700 group animals was better than that of the control group (0%; P < 0.01). CONCLUSION:
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Authors | Tsuyoshi Ohno, Katsunori Kawano, Atsushi Sasaki, Masanori Aramaki, Kouichirou Tahara, Tsuyoshi Etoh, Seigo Kitano |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 7
Issue 3
Pg. 171-6
(Jun 2002)
ISSN: 1341-9625 [Print] Japan |
PMID | 12109519
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Antineoplastic Agents
- Tubulin
- Serine
- AC 7700
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Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Animals
- Antineoplastic Agents
(therapeutic use)
- Disease Models, Animal
- Liver Neoplasms, Experimental
(blood supply, drug therapy, pathology)
- Male
- Neoplasm Transplantation
- Neovascularization, Pathologic
(drug therapy, pathology)
- Rats
- Serine
(analogs & derivatives, therapeutic use)
- Survival Rate
- Tubulin
(metabolism)
- Tumor Cells, Cultured
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