Influence of hypertension on tetrahydropapaveroline-induced vasorelaxation in rat thoracic aorta.
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| Abstract |
Tetrahydropapaveroline (THP), a condensation product of ethanol-derived acetaldehyde, has been shown to elicit a vasorelaxant response in rat thoracic aorta. This study examined the influence of hypertension on the THP-induced vasorelaxant responsiveness. Ring segments of thoracic aorta were isolated from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) and isometric tension development was measured with a force transducer. In aorta, with or without intact endothelium, the contractile responses to potassium chloride (0-120 mM) were comparable between the WKY and the SHR groups. Hypertension did not affect the vasoconstrictive response to norepinephrine (0-10 microM) in vessels with intact endothelium, whereas it attenuated the norepinephrine-induced response in vessels without endothelium. THP (0.1-100 microM) elicited endothelium-intact as well as -denuded vasorelaxation in aorta from both WKY and SHR groups. Interestingly, the THP-induced endothelium-dependent vasorelaxation was significantly enhanced, whereas the THP-induced endothelium-independent vasorelaxation was not affected by hypertension. These data indicate that the THP-induced endothelium-dependent vasorelaxant response is altered by the hypertensive state.
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| Authors | Ricardo A Brown, Karl J Ilg, Jun Ren |
| Journal | Endocrine research (Endocr Res) 2002 Feb-May Vol. 28 Issue 1-2 Pg. 19-26 ISSN: 0743-5800 [Print] England |
| PMID | 12108786 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.) |
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