[Adrenal cortex response to prolonged administration of low doses of magnesium chlorate in rats].

Abstract

Rat adrenals were studied using histological and histochemical methods during prolonged intoxication with pesticide magnesium chlorate which was administered in a dose equal to 1/100 of LD50 (41 mg/kg of body weight). Animals that received distilled water and were kept in similar conditions were used as control. It was demonstrated that intoxication of rats for 3-7 days results in increased secretory activity of all the zones of adrenal cortex. Later (after 14-90 days) the zonal response to pesticide administration was variable. Magnesium chlorate treatment results in the disturbances of hormonal synthesis in adrenocorticocytes. Compensatory-adaptive capacities of zona fasciculata were found to be greater than those in zona glomerulosa and zona reticularis.

• Authors: S A Blinova, S A Ten, Sh E Islamov
• Journal: Morfologiia (Saint Petersburg, Russia) (Morfologiia) Vol. 121 Issue 1 Pg. 27-30 ( 2002) ISSN: 1026-3543 [Print] Russia (Federation)
• Vernacular Title: Reaktsiia kory nadpochechnikov krys na dlitel'noe vvedenie khlorata magniia v malykh dozakh.
• PMID: 12108096 (Publication Type: English Abstract, Journal Article)

Chemical References

• Chlorates
• Magnesium Compounds
• RNA
• Glycogen
• magnesium chlorate

Topics

• Administration, Oral
• Adrenal Cortex (drug effects, metabolism, pathology)
• Animals
• Chlorates (administration & dosage, toxicity)
• Glycogen (metabolism)
• Immunohistochemistry
• Lethal Dose 50
• Lipid Metabolism
• Magnesium Compounds (administration & dosage, toxicity)
• Male
• RNA (metabolism)
• Rats
• Time Factors
• Zona Fasciculata (drug effects, metabolism, pathology)
• Zona Reticularis (drug effects, metabolism, pathology)