[Diagnostic value of hemostasis activation markers in acute deep vein thrombosis].

Abstract	The aim of the following study was to evaluate the diagnostic value of selective hemostasis activation markers, prothrombin activation fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex (TAT), plasmin-alpha 2-antiplasmin complex (PAP) and D-dimer in patients with acute deep venous thrombosis (DVT). The study was performed on 56 patients with freshly diagnosed acute DVT confirmed by venography. The study indicated that patients with acute venous thrombosis have increased concentrations of F1 + 2, TAT complex, PAP complex and D-dimer in blood plasma. The statistical analysis showed that F1 + 2 is the most sensitive test while the D-dimer measurement proved to be the most specific in diagnosing DVT. The conducted logistic regression showed that the most reliable parameter that confirms the existence of acute venous thrombosis is the D-dimer test. The measurement of both F1 + 2 and the D-dimer concentrations rises the reliability of the DVT up to 97%.
Authors	Elzbieta Tajanko, Marzenna Galar, Jarosław Piszcz, Janusz Kłoczko
Journal	Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 107 Issue 3 Pg. 237-41 (Mar 2002) Poland
Vernacular Title	Diagnostyczne znaczenie oznaczania markerów aktywacji hemostazy w ostrej zakrzepicy zył głebokich.
PMID	12107982 (Publication Type: English Abstract, Journal Article)
Chemical References	Antifibrinolytic Agents Biomarkers Fibrin Fibrinogen Degradation Products Peptide Fragments alpha-2-Antiplasmin antithrombin III-protease complex fibrin fragment D plasmin-plasmin inhibitor complex prothrombin fragment 1.2 Antithrombin III Prothrombin Peptide Hydrolases Fibrinolysin
Topics	Acute Disease Adolescent Adult Aged Aged, 80 and over Antifibrinolytic Agents (blood) Antithrombin III Biomarkers (blood) Case-Control Studies Female Fibrin Fibrinogen Degradation Products (metabolism) Fibrinolysin Hemostasis Humans Logistic Models Male Peptide Fragments (blood) Peptide Hydrolases (blood) Prothrombin Sensitivity and Specificity Statistics, Nonparametric Venous Thrombosis (blood, diagnosis) alpha-2-Antiplasmin

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