Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour.

Abstract

The case of a 33-year-old-woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone-releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha-subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.

• Authors: E Boix, A Picó, R Pinedo, I Aranda, K Kovacs
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 57 Issue 1 Pg. 131-4 (Jul 2002) ISSN: 0300-0664 [Print] England
• PMID: 12100081 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Neoplasm Proteins
• Peptides, Cyclic
• lanreotide
• Vasoactive Intestinal Peptide
• Somatostatin
• Growth Hormone-Releasing Hormone

Topics

• Acromegaly (drug therapy, etiology)
• Adult
• Antineoplastic Agents (therapeutic use)
• Carcinoid Tumor (chemistry, drug therapy, metabolism)
• Fatal Outcome
• Female
• Germ-Line Mutation
• Growth Hormone-Releasing Hormone (analogs & derivatives, analysis, metabolism)
• Humans
• Immunohistochemistry
• Multiple Endocrine Neoplasia Type 1 (chemistry, drug therapy, genetics, metabolism)
• Neoplasm Proteins (analysis, metabolism)
• Peptides, Cyclic (therapeutic use)
• Somatostatin (analogs & derivatives, analysis, therapeutic use)
• Thymus Neoplasms (chemistry, metabolism)
• Vasoactive Intestinal Peptide (analysis)