HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The involvement of 5-HT3 and 5-HT4 receptors in two models of gastrointestinal transit in mice.

Abstract
Our aim was to study the involvement of 5-hydroxytryptamine (5-HT)(3) and 5-HT(4) receptors in two models of gastrointestinal transit (GIT) in mice: the 5-hydroxytryptophan (5-HTP)-induced diarrhea and intestinal inflammation produced by an irritant agent, croton oil (CO). 5-HTP (10 mg/kg) produced diarrhea that was significantly inhibited after pretreatment with ondansetron (5-HT(3) antagonist) or RS 39604 (5-HT(4) antagonist) (1-5 mg/kg). The GIT speed was increased after CO and 5-HTP administration. 5-HT(3-4) antagonists decreased GIT after 5-HTP-treatment but not after CO-treatment. Our results show that 5-HT(3) and 5-HT(4) receptors are involved in 5-HTP-induced diarrhea. This may be the reason why 5-HT(3-4) antagonists could be useful in the treatment of carcinoid syndrome diarrhea. 5-HT(3-4) antagonists were not effective in the modifications of GIT; nevertheless, they could be useful in the treatment of inflammatory bowel diseases because some symptoms as abdominal pain, discomfort or abnormal bowel function are modulated via 5-HT(3).
AuthorsD Pascual, A Alsasua, C Goicoechea, M I Martín
JournalNeuroscience letters (Neurosci Lett) Vol. 326 Issue 3 Pg. 163-6 (Jul 05 2002) ISSN: 0304-3940 [Print] Ireland
PMID12095647 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antidiarrheals
  • Dermatologic Agents
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists
  • Receptors, Serotonin, 5-HT4
  • Serotonin
  • Ondansetron
  • Morphine
  • Croton Oil
  • 5-Hydroxytryptophan
Topics
  • 5-Hydroxytryptophan (pharmacology)
  • Animals
  • Antidiarrheals (pharmacology)
  • Croton Oil (pharmacology)
  • Dermatologic Agents (pharmacology)
  • Diarrhea (chemically induced, drug therapy)
  • Gastrointestinal Transit (physiology)
  • Intestines (drug effects)
  • Male
  • Mice
  • Morphine (pharmacology)
  • Ondansetron (pharmacology)
  • Receptors, Serotonin (metabolism)
  • Receptors, Serotonin, 5-HT3
  • Receptors, Serotonin, 5-HT4
  • Serotonin (pharmacology)
  • Serotonin Antagonists (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: