Abstract |
Our aim was to study the involvement of 5-hydroxytryptamine (5-HT)(3) and 5-HT(4) receptors in two models of gastrointestinal transit (GIT) in mice: the 5-hydroxytryptophan (5-HTP)-induced diarrhea and intestinal inflammation produced by an irritant agent, croton oil (CO). 5-HTP (10 mg/kg) produced diarrhea that was significantly inhibited after pretreatment with ondansetron (5-HT(3) antagonist) or RS 39604 (5-HT(4) antagonist) (1-5 mg/kg). The GIT speed was increased after CO and 5-HTP administration. 5-HT(3-4) antagonists decreased GIT after 5-HTP-treatment but not after CO-treatment. Our results show that 5-HT(3) and 5-HT(4) receptors are involved in 5-HTP-induced diarrhea. This may be the reason why 5-HT(3-4) antagonists could be useful in the treatment of carcinoid syndrome diarrhea. 5-HT(3-4) antagonists were not effective in the modifications of GIT; nevertheless, they could be useful in the treatment of inflammatory bowel diseases because some symptoms as abdominal pain, discomfort or abnormal bowel function are modulated via 5-HT(3).
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Authors | D Pascual, A Alsasua, C Goicoechea, M I Martín |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 326
Issue 3
Pg. 163-6
(Jul 05 2002)
ISSN: 0304-3940 [Print] Ireland |
PMID | 12095647
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidiarrheals
- Dermatologic Agents
- Receptors, Serotonin
- Receptors, Serotonin, 5-HT3
- Serotonin Antagonists
- Receptors, Serotonin, 5-HT4
- Serotonin
- Ondansetron
- Morphine
- Croton Oil
- 5-Hydroxytryptophan
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Topics |
- 5-Hydroxytryptophan
(pharmacology)
- Animals
- Antidiarrheals
(pharmacology)
- Croton Oil
(pharmacology)
- Dermatologic Agents
(pharmacology)
- Diarrhea
(chemically induced, drug therapy)
- Gastrointestinal Transit
(physiology)
- Intestines
(drug effects)
- Male
- Mice
- Morphine
(pharmacology)
- Ondansetron
(pharmacology)
- Receptors, Serotonin
(metabolism)
- Receptors, Serotonin, 5-HT3
- Receptors, Serotonin, 5-HT4
- Serotonin
(pharmacology)
- Serotonin Antagonists
(pharmacology)
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