Evaluation of cisplatin in combination with a biologic response modifier in a murine mammary carcinoma model.

Abstract	The purpose of this study was to determine the efficacy of intracavitary cisplatin against local regrowth and metastasis after resection of a murine mammary carcinoma and the ability of a biologic response modifier (Virulizin) to enhance chemotherapy. C3H-HeJ mice were injected with Gollin-B tumor cells. Once growth reached 8 mm, tumors underwent marginal resection and the mice were assigned randomly to intraperitoneal (i.p.) cisplatin, Virulizin, a controlled release cisplatin-impregnated sponge (OPLA-Pt), a combination of treatments or no treatment and were evaluated for local regrowth, metastasis, and toxicity at 14 or 60 days after surgery. A possible beneficial interaction was seen between OPLA-Pt and Virulizin at 14 days. All cisplatin groups had significant advantages over controls in all variables measured with OPLA-Pt displaying significant advantages over i.p. cisplatin in local recurrence rate, tumor score, survival time, and delay in regrowth at 60 days. No toxicity related to either cisplatin or Virulizin was observed.
Authors	Emanuela Morello, William S Dernell, Charles A Kuntz, Susan M LaRue, Mary Lafferty, Ann Nelson, John H Brekke, Craig H Mallinckrodt, Stephen J Withrow, Mark C Manning
Journal	Cancer investigation (Cancer Invest) Vol. 20 Issue 4 Pg. 480-9 ( 2002) ISSN: 0735-7907 [Print] England
PMID	12094543 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adjuvants, Immunologic Antineoplastic Agents Delayed-Action Preparations Immunologic Factors Polyesters Polymers Tissue Extracts virulizin Lactic Acid poly(lactide) Cisplatin
Topics	Adenocarcinoma (drug therapy, mortality, pathology) Adjuvants, Immunologic (therapeutic use) Animals Antineoplastic Agents (therapeutic use) Bile Cisplatin (therapeutic use) Delayed-Action Preparations Drug Therapy, Combination Female Immunologic Factors (therapeutic use) Injections, Intraperitoneal Lactic Acid Mammary Neoplasms, Experimental (drug therapy, mortality, pathology) Mice Mice, Inbred C3H Neoplasm Recurrence, Local (drug therapy, pathology) Polyesters Polymers Survival Rate Tissue Extracts

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