Abstract | BACKGROUND: HISTORY AND SIGNS: THERAPY AND OUTCOME: Topical CsA 2 % ( eye drops, 3 times daily) was administered in addition to lubricants. After 3 months the deep corneal neovascularisations were significantly reduced. The corneal ulcer was closed and visual acuity increased from 20/400 (OU) to 20/100 (OD) and 20/200 (OS), respectively. CONCLUSION: A dose-dependent keratinocyte growth inhibition was found in vitro for cyclosporin A using ichthyosis skin samples. The reduction of activated T-lymphocytes and the resulting reduced HLA-Class-2 expression of conjunctiva and cornea as well as the inhibition of activated T-Cells in the lacrimal gland might be responsible. Nevertheless, the effect of topical CsA on the vascularizing keratitis in the KID syndrome is unknown.
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Authors | Matthias Derse, Elisabeth Wannke, H Payer, Jens Martin Rohrbach, Manfred Zierhut |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 219
Issue 5
Pg. 383-6
(May 2002)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | Erfolgreiche topische Cyclosporin-A-Therapie bei progredienter vaskularisierender ulzerierender Keratitis beim Keratitis-Ichthyosis-Deafness(KID)-Syndrom. |
PMID | 12094324
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Ophthalmic Solutions
- Cyclosporine
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Topics |
- Adult
- Corneal Neovascularization
(diagnosis, drug therapy)
- Corneal Ulcer
(diagnosis, drug therapy)
- Cyclosporine
(administration & dosage, adverse effects)
- Deafness
(diagnosis)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Follow-Up Studies
- Humans
- Ichthyosis
(diagnosis)
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Male
- Ophthalmic Solutions
- Syndrome
- Wound Healing
(drug effects)
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