Abstract | OBJECTIVE: To evaluate the efficacy of inhaled albuterol for treatment of hyperkalemia in premature neonates by conducting a prospective, randomized placebo-controlled and double-blinded clinical trial. STUDY DESIGN: Neonates <2000 g receiving mechanical ventilation with central serum potassium > or =6.0 mmol/L (6.0 mEq/L), were randomly assigned to treatment or placebo groups. Albuterol (400 microg) or saline was given by nebulization. The dose was repeated every 2 hours until the potassium level fell below 5 mmol/L (maximum 12 doses) or there were signs of toxicity. RESULTS: Nineteen patients completed the study (8 in the albuterol and 11 in the saline group). Serum potassium levels declined rapidly in the first 4 hours in the albuterol group, from 7.06 +/- 0.23 mmol/L to 6.34 +/- 0.24 mmol/L (P =.003) versus no significant change in the saline group (6.88 +/- 0.18 mmol/L to 6.85 +/- 0.24 mmol/L; P =.87). At 8 hours, the fall continued to be greater in the albuterol group versus the saline group (5.93 +/- 0.3 mmol/L and 6.35 +/- 0.22 mmol/L, respectively; P =.04). CONCLUSION:
Albuterol inhalation may be useful in rapidly lowering serum potassium levels in premature neonates.
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Authors | Bindya S Singh, H Farouk Sadiq, Akihiko Noguchi, William J Keenan |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 141
Issue 1
Pg. 16-20
(Jul 2002)
ISSN: 0022-3476 [Print] United States |
PMID | 12091845
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Agonists
- Albuterol
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Topics |
- Administration, Inhalation
- Adrenergic beta-Agonists
(therapeutic use)
- Albuterol
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hyperkalemia
(drug therapy)
- Infant, Newborn
- Infant, Premature
- Male
- Prospective Studies
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