[Oxygen transport and immune status in patients with congenital valvular heart disease].

Abstract

Oxygen transport, its metabolic maintenance and immune status were studied in 17 patients with congenital valvular heart disease (CVD) having compensated (n = 8, group 1) and decompensated (n = 9, group 2) defects of hemodynamics. CVD patients with decompensated central hemodynamics and progressing hypoxia had impaired compensatory rearrangement of oxygen transport system. Accumulation of intracellular lactate, low activity of basic energetic cycles of blood cells most evident in decompensated CVD was observed in both the groups. In conditions of severe energy-structural deficiency and impaired function of oxygen transport systems, CVD patients develop secondary immune deficiency presenting with depression of basic immunoregulatory subpopulations of T- and B- cellular immunity (CD2, CD3, CD4, CD5, CD8, CD16, CD22).

• Authors: I V Dudarev, A D Bagment, A A Diuzhikov, S V Shlyk
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 80 Issue 5 Pg. 19-21 ( 2002) ISSN: 0023-2149 [Print] Russia (Federation)
• Vernacular Title: Osobennosti transporta kisloroda i immunogo statusa u bol'nykh vrozhdennymi porokami serdtsa.
• PMID: 12087880 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, CD
• Oxygen

Topics

• Antigens, CD (immunology)
• Heart Valve Diseases (congenital, immunology, metabolism)
• Hemodynamics (physiology)
• Humans
• Oxygen (metabolism)