Abstract |
A taste-aversion paradigm was used to demonstrate that aversive consequences accompany the rapid oral ingestion of 5% (v/v) ethanol solutions. The learned taste aversion resulted from five 10-min self-administrations of alcohol mixed with an originally preferred flavor at a dosage of 1.69 g alcohol/kg body weight/day. In contrast, when the consumption of the alcohol solution was distributed throughout the day, a conditioned aversion was not obtained. This outcome was observed even though the distributed drinking animals were exposed to more orosensory stimuli and ingested more g/kg than the 10-min animals. The observation that those animals that drank their daily fluid in 10 min demonstrated higher peak blood-alcohol levels than the distributed animals supports the conclusion that a centrally mediated aversive state of inebriation must be present to produce a conditioned aversion.
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Authors | M J Eckardt |
Journal | Psychopharmacologia
(Psychopharmacologia)
Vol. 44
Issue 3
Pg. 267-71
(Nov 21 1975)
Germany |
PMID | 1208761
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Alcohol Drinking
- Animals
- Avoidance Learning
- Conditioning, Psychological
- Ethanol
(blood, pharmacology)
- Female
- Rats
- Reinforcement Schedule
- Taste
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