Abstract | BACKGROUND: METHODS: We interviewed women who were 35 to 64 years old. A total of 4575 women with breast cancer and 4682 controls were interviewed. Conditional logistic regression was used to calculate odds ratios as estimates of the relative risk (incidence-density ratios) of breast cancer. RESULTS: The relative risk was 1.0 (95 percent confidence interval, 0.8 to 1.3) for women who were currently using oral contraceptives and 0.9 (95 percent confidence interval, 0.8 to 1.0) for those who had previously used them. The relative risk did not increase consistently with longer periods of use or with higher doses of estrogen. The results were similar among white and black women. Use of oral contraceptives by women with a family history of breast cancer was not associated with an increased risk of breast cancer, nor was the initiation of oral-contraceptive use at a young age. CONCLUSIONS:
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Authors | Polly A Marchbanks, Jill A McDonald, Hoyt G Wilson, Suzanne G Folger, Michele G Mandel, Janet R Daling, Leslie Bernstein, Kathleen E Malone, Giske Ursin, Brian L Strom, Sandra A Norman, Phyllis A Wingo, Ronald T Burkman, Jesse A Berlin, Michael S Simon, Robert Spirtas, Linda K Weiss |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 346
Issue 26
Pg. 2025-32
(Jun 27 2002)
ISSN: 1533-4406 [Electronic] United States |
PMID | 12087137
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Body Mass Index
- Breast Neoplasms
(epidemiology, genetics)
- Case-Control Studies
- Contraceptives, Oral
(adverse effects)
- Female
- Humans
- Logistic Models
- Menopause
- Middle Aged
- Risk Factors
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