Abstract |
To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of polymorphism 1359G/A at codon 453 in the coding region and AAT triplet repeats in the 3' flanking region in the Japanese population were quite different from those in Caucasians. Although the polymorphism 1359G/A was not associated with schizophrenia, the triplet repeat polymorphism of the CNR1 gene was significantly associated with schizophrenia, especially the hebephrenic subtype (P = 0.0028). Hebephrenic schizophrenia showed significantly increased rate of the 9 repeat allele (P = 0.032, OR = 2.30, 95% CI (1.91-2.69)), and decreased rate of the 17 repeat allele (P = 0.011, OR = 0.208, 95% CI (0.098-0.439)). The present findings indicated that certain alleles or genotypes of the CNR1 gene may confer a susceptibility of schizophrenia, especially of the hebephrenic type.
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Authors | H Ujike, M Takaki, K Nakata, Y Tanaka, T Takeda, M Kodama, Y Fujiwara, A Sakai, S Kuroda |
Journal | Molecular psychiatry
(Mol Psychiatry)
Vol. 7
Issue 5
Pg. 515-8
( 2002)
ISSN: 1359-4184 [Print] England |
PMID | 12082570
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Codon
- DNA Primers
- Receptors, Cannabinoid
- Receptors, Drug
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Topics |
- Adult
- Asian People
(genetics)
- Base Sequence
- Codon
(genetics)
- DNA Primers
- Female
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Humans
- Japan
- Male
- Polymorphism, Single Nucleotide
- Receptors, Cannabinoid
- Receptors, Drug
(genetics)
- Reference Values
- Schizophrenia
(genetics)
- Schizophrenia, Disorganized
(genetics)
- Schizophrenia, Paranoid
(genetics)
- Trinucleotide Repeats
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