Abstract | OBJECTIVE: DESIGN: A prospective cohort study within a randomised, double-blind, placebo-controlled trial testing supplementation with alpha-tocopherol (50 mg/day), beta-carotene (20 mg/day) or both in preventing cancer. SUBJECTS AND METHODS: Participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study with complete dietary data and serum samples available from baseline. These included 26,951 middle-aged male smokers among whom 184 colorectal cancer cases were diagnosed during 8 y of follow-up. Relative risks were calculated with Cox proportional hazards models adjusting for trial supplementation, age, body mass index, serum cholesterol, cigarettes smoked per day and physical activity. RESULTS: CONCLUSIONS: SPONSORSHIP:
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Authors | N Malila, J Virtamo, M Virtanen, P Pietinen, D Albanes, L Teppo |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 56
Issue 7
Pg. 615-21
(Jul 2002)
ISSN: 0954-3007 [Print] England |
PMID | 12080400
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticarcinogenic Agents
- Antioxidants
- beta Carotene
- Vitamin A
- alpha-Tocopherol
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Topics |
- Aged
- Anticarcinogenic Agents
(administration & dosage, blood)
- Antioxidants
(administration & dosage, metabolism)
- Cohort Studies
- Colorectal Neoplasms
(blood, prevention & control)
- Dietary Supplements
- Double-Blind Method
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Smoking
- Vitamin A
(administration & dosage, blood)
- alpha-Tocopherol
(administration & dosage, blood)
- beta Carotene
(administration & dosage, blood)
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