Abstract | OBJECTIVES: METHOD: Male rats were injected 450 pmol PACAP or VIP dissolved in physiological saline intracerebroventricularly, preceding the occlusion of the middle cerebral artery. Control animals received vehicle treatment. Permanent focal ischemia was induced by the intraluminal filament occlusion of the middle cerebral artery. Animals were sacrificed 12 or 24 hours after the onset of ischemia, and infarcted brain areas were determined by staining bran sections with triphenyl-tetrazolium chloride. RESULTS: Twelve hours after ischemia, the infarcted brain volume resulted to be 14.8% in the control group, 15.3% in the VIP-treated group and 5.8% in the PACAP-treated animals. Twenty-four hours after middle cerebral artery occlusion, the infarcted brain volumes were 21.5%, 20.7% and 14.3% in the control, VIP and PACAP-treated animals, respectively. CONCLUSION:
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Authors | Andrea Tamás, Dóra Reglõdi, Zalán Szántó, Balázs Borsiczky, József Németh, István Lengvári |
Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 23
Issue 3
Pg. 249-54
(Jun 2002)
ISSN: 0172-780X [Print] Sweden |
PMID | 12080287
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adcyap1 protein, rat
- Neuropeptides
- Neuroprotective Agents
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Vasoactive Intestinal Peptide
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Topics |
- Animals
- Body Temperature
- Brain Ischemia
(pathology, prevention & control)
- Infarction, Middle Cerebral Artery
(drug therapy, pathology)
- Male
- Neuropeptides
(pharmacology)
- Neuroprotective Agents
(pharmacology)
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Rats
- Rats, Wistar
- Vasoactive Intestinal Peptide
(pharmacology)
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