Abstract | OBJECTIVE: METHODS: Alterations in ST mRNA expression in FIGO IB1 cervical squamous cell carcinomas (n = 79) were examined by semiquantitative reverse transcription-polymerase chain reaction. RESULTS: Both ST6Gal I mRNA and ST3Gal III mRNA expressions were significantly increased in patients with lymph node metastases compared to those without lymph node metastases (P = 0.002 and P = 0.001, respectively, Mann-Whitney U test). Using receiver operating characteristic curves of ST ratio index for accuracy comparison of lymph node metastases, ST3Gal III and ST6Gal I were observed to be fairly interchangeable (area under the curve (AUC) of 3Gal I = 0.810; AUC of 6Gal I = 0.786, significance of difference between AUC = 0.810). High ST6Gal I expression was associated with other invasive properties of cervical cancer, such as deep stromal invasion and presence of lymph-vascular space involvement. ST6Gal I expression seemed to be more enhanced in bigger tumors. CONCLUSIONS:
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Authors | Peng-Hui Wang, Ywan Feng Li, Chi-Mou Juang, Yan-Ru Lee, Hsiang-Tai Chao, Heung-Tat Ng, Ying-Chieh Tsai, Chiou-Chung Yuan |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 86
Issue 1
Pg. 45-52
(Jul 2002)
ISSN: 0090-8258 [Print] United States |
PMID | 12079299
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2002 Elsevier Science (USA). |
Chemical References |
- Isoenzymes
- RNA, Messenger
- Sialyltransferases
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Topics |
- Carcinoma, Squamous Cell
(enzymology, pathology)
- Female
- Humans
- Isoenzymes
(biosynthesis, genetics)
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Neoplasm Staging
- Prospective Studies
- RNA, Messenger
(biosynthesis, genetics)
- ROC Curve
- Regression Analysis
- Reverse Transcriptase Polymerase Chain Reaction
- Sialyltransferases
(biosynthesis, genetics)
- Uterine Cervical Neoplasms
(enzymology, pathology)
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