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Kikuchi-Fujimoto's disease: report of familial occurrence in two human leucocyte antigen-identical non-twin sisters.

Abstract
Kikuchi-Fujimoto's disease (KFD) is a self-limiting condition usually presenting as cervical lymphadenopathy, with fever and leukopenia, in young adult females. No specific aetiology has been identified yet, although some authors believe that KFD is a 'forme fruste' of systemic lupus erythematosus. Certain human leucocyte antigen (HLA) types have also been associated with KFD. We herein report KFD in two non-twin sisters with HLA-identical phenotype, who presented 10 years apart. Neither patient had evidence of recent infection or connective tissue disease. The familial occurrence emphasizes the possibility of genetic predisposition and calls for a more extensive search for a specific cause of KFD.
AuthorsA R A Amir, S S Amr, S S Sheikh
JournalJournal of internal medicine (J Intern Med) Vol. 252 Issue 1 Pg. 79-83 (Jul 2002) ISSN: 0954-6820 [Print] England
PMID12074742 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HLA Antigens
Topics
  • Adult
  • Female
  • HLA Antigens (genetics)
  • Histiocytic Necrotizing Lymphadenitis (genetics, pathology, surgery)
  • Humans
  • Nuclear Family
  • Phenotype

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