Binding of the mammalian homolog of the Drosophila discs large tumor suppressor protein to the ribosome receptor.

Abstract

DLG, the mammalian homolog of the Drosophila Discs Large suppressor protein, functions as a scaffolding protein that facilitates the transmission of diverse downstream signals. In the present study, we attempted to identify partner proteins for DLG, and found that DLG interacts through its PDZ domains with the ribosome receptor. The ribosome receptor is an integral endoplasmic reticulum protein that has been suggested to be involved in secretion. Our finding raises the possibility that DLG plays a role in the regulation of secretion by interacting with the ribosome receptor.

• Authors: Minji Kim, Hironori Ogawa, Kazuyoshi Kohu, Minoru Ichikawa, Kiyotoshi Satoh, Takefumi Ishidao, Shigeyuki Nada, Tetsu Akiyama
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 294 Issue 5 Pg. 1151-4 (Jun 28 2002) ISSN: 0006-291X [Print] United States
• PMID: 12074597 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• DLG1 protein, human
• Discs Large Homolog 1 Protein
• Membrane Proteins
• Proteins
• Receptors, Amino Acid
• Receptors, Cytoplasmic and Nuclear
• Tumor Suppressor Proteins
• ribosome receptor

Topics

• Adaptor Proteins, Signal Transducing
• Amino Acid Sequence
• Animals
• Discs Large Homolog 1 Protein
• HeLa Cells
• Humans
• Membrane Proteins
• Molecular Sequence Data
• Proteins (metabolism)
• Receptors, Amino Acid
• Receptors, Cytoplasmic and Nuclear (chemistry, metabolism)
• Swine
• Tumor Suppressor Proteins (metabolism)