Screening for osteoporosis in patients with inflammatory bowel disease by using urinary N-telopeptides.

Abstract

BACKGROUND:

Patients with inflammatory bowel disease are at increased risk of osteoporosis.

DESIGN AND METHODS:

We carried out a prospective study of bone mineral density and biochemical markers of bone metabolism like osteocalcin and urinary N-telopeptides in 72 patients with inflammatory bowel disease and evaluated if one of these markers detects osteoporosis. In addition, bone mineral density and N-telopeptides were analysed retrospectively in a second series of 93 patients with inflammatory bowel disease in order to assess predictive values found in the first patient group in an independent sample.

RESULTS:

Multiple linear regression showed that N-telopeptides (P < 0.0001) and total white blood cell count (P = 0.006) correlated negatively with the bone mineral density of the lumbar spine and only N-telopeptides (P = 0.005) correlated negatively with the bone mineral density of the femoral neck. Using receiver operator characteristic curves N-telopeptide concentrations of > 40 (30) nmol N-telopeptides/mmol creatinine were chosen as best cut-off values to exclude osteoporosis at the lumbar spine (femoral neck). Using these cut-off values a negative predictive value of 100% (100%) and a positive predictive value of 37.5% (27.9%) were found in the first group, and a negative predictive value of 95.2% (96%) and a positive predictive value of 15.6% (23.3%) in the second, independent group of patients.

CONCLUSION:

Our data suggest that N-telopeptide levels could be used as a tool for the screening of osteoporosis and for selecting those inflammatory bowel disease patients where bone mineral density measurement is indicated.

• Authors: Nicole Bregenzer, Peter Erban, Helga Albrich, Gerd Schmitz, Stefan Feuerbach, Jürgen Schölmerich, Tilo Andus
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 14 Issue 6 Pg. 599-605 (Jun 2002) ISSN: 0954-691X [Print] England
• PMID: 12072593 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Peptides

Topics

• Adult
• Biomarkers (urine)
• Bone Density
• Female
• Femur
• Humans
• Inflammatory Bowel Diseases (complications)
• Leukocyte Count
• Male
• Middle Aged
• Osteoporosis (diagnosis)
• Peptides (urine)
• Predictive Value of Tests
• Prospective Studies
• ROC Curve
• Regression Analysis