Abstract | BACKGROUND:
Fibrosis is one of the major causes of post-treatment morbidity in tuberculosis. The molecular basis of fibrosis in active and healed tuberculous lesions is yet to be fully characterized. OBJECTIVES: PATIENTS AND METHODS: RESULTS: It was found that collagen, elastin, fibronectin and TGF-beta levels were higher in the active lesions. The levels of zinc were similar in both active and healed lesions. Clinically, scar tissue or keloid formation was not seen in any of the healed lesions. CONCLUSIONS: Effective antituberculous chemotherapy will lead to a substantial reduction of fibrosis and the consequent disability that can arise in patients with tuberculosis.
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Authors | K Jayasankar, H Shakila, K C Umapathy, V D Ramanathan |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 146
Issue 6
Pg. 977-82
(Jun 2002)
ISSN: 0007-0963 [Print] England |
PMID | 12072065
(Publication Type: Journal Article)
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Chemical References |
- Antitubercular Agents
- Fibronectins
- Transforming Growth Factor beta
- Collagen
- Elastin
- Zinc
- Isoniazid
- Rifampin
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Topics |
- Antitubercular Agents
(therapeutic use)
- Biopsy
(methods)
- Collagen
(analysis)
- Elastin
(analysis)
- Fibronectins
(analysis)
- Fibrosis
- Humans
- Immunohistochemistry
(methods)
- Isoniazid
(therapeutic use)
- Rifampin
(therapeutic use)
- Transforming Growth Factor beta
(analysis)
- Tuberculosis, Cutaneous
(drug therapy, pathology)
- Zinc
(analysis)
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