Abstract | BACKGROUND: MATERIAL/METHODS: A total of 1950 students (918 females, 1032 males, ages between 14 and 17) were screened by the Fluorescent Spot Test, and the G6PD deficiency was confirmed by quantitative spectrophotometric assay. The G6PD deficient subjects were further analyzed by the PCR/RFLP technique to identify the presence of the 563 T Mediterranean mutation. RESULTS: 24 of the subjects were found to be deficient in this enzyme, a frequency of 1.23%. Of 24 deficient subjects, 19 (79%) had the 563 T Mediterranean mutation. CONCLUSIONS: The frequency of G6PD enzyme deficiency appears to be low compared with those found in the malaria-endemic Mediterranean region of Turkey. The molecular pathology of G6PD deficiency is related to the G6PD-563 T mutation in the Denizli region.
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Authors | Nazan Keskin, Ibrahim Ozdes, Ali Keskin, Ibrahim Acikbas, Huseyin Bagci |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 8
Issue 6
Pg. CR453-6
(Jun 2002)
ISSN: 1234-1010 [Print] United States |
PMID | 12070439
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Base Sequence
- DNA Primers
- Female
- Glucosephosphate Dehydrogenase Deficiency
(epidemiology)
- Humans
- Incidence
- Male
- Turkey
(epidemiology)
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