Abstract |
Statins, anti-hypercholesterolemic agents, have previously been reported to induce apoptosis and exert antitumor activity when combined with other antitumor agents. The potential of lovastatin in combination with highly specific COX-2 inhibitor ( MF-tricyclic) to induce anti-proliferative activity against tumour cells was evaluated using the combination index (CI) method. Murine colorectal cancer (colon-26, CMT-93), melanoma (B16F10) and human bladder carcinoma cells (T24) were tested. Exposure of colon-26 and CMT-93 cells resulted in synergistic interactions in both cell lines with CI<1 for 20-80% inhibition of cell growth in both cell lines. This synergy was not observed in the B16F10 melanoma and T24 bladder carcinoma cells. MF-tricyclic (40 microg/ml), augmented lovastatin-induced apoptosis up to 2.5-fold in colon-26 cancer cells. Combination of a specific COX-2 inhibitor, MF-tricyclic, may increase antiproliferative effects of lovastatin in colon cancer cells and this effect was due to an augmented apoptosis.
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Authors | Wojciech Feleszko, Ahmad Jalili, Dominika Olszewska, Izabela Mlynarczuk, Tomasz Grzela, Adam Giermasz, Marek Jakóbisiak |
Journal | Oncology reports
(Oncol Rep)
2002 Jul-Aug
Vol. 9
Issue 4
Pg. 879-85
ISSN: 1021-335X [Print] Greece |
PMID | 12066226
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors
- Furans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Isoenzymes
- Membrane Proteins
- Tetrazolium Salts
- Thiazoles
- 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone
- Lovastatin
- Cyclooxygenase 2
- PTGS2 protein, human
- Prostaglandin-Endoperoxide Synthases
- thiazolyl blue
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Topics |
- Adenocarcinoma
(drug therapy, metabolism)
- Animals
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Cell Division
(drug effects)
- Colorectal Neoplasms
(drug therapy, metabolism)
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors
(pharmacology)
- Drug Interactions
- Drug Synergism
- Drug Therapy, Combination
- Furans
(pharmacology)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology)
- Isoenzymes
(antagonists & inhibitors)
- Lovastatin
(pharmacology)
- Melanoma
(drug therapy, metabolism)
- Membrane Proteins
- Mice
- Prostaglandin-Endoperoxide Synthases
- Tetrazolium Salts
- Thiazoles
- Tumor Cells, Cultured
(drug effects, metabolism)
- Urinary Bladder Neoplasms
(drug therapy, metabolism)
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