| Abstract | OBJECTIVES: To evaluate the clinical usefulness of preoperative transcatheter arterial infusion chemotherapy (TAIC) for locally advanced breast cancer. METHODS: Seven patients with unresectable locally advanced breast cancer (stage IIIb) underwent TAIC percutaneously 1-3 times (mean, 1.7 times) until tumors became resectable. Anticancer drugs were injected into both the internal mammary and the distal subclavian arteries. RESULTS: There was no major complication related to the procedure. The mean tumor size was significantly decreased from 10.0+/-3.9 to 5.1+/-2.5 cm (P=0.0086). Skin and muscle invasions were improved in two patients (28%) and lymph nodes disappeared in one patient (14%). In two patients (28%), down-staging was achieved from stage IIIb to stage IIIa. All tumors turned into resectable, and mastectomy was performed with a mean period of 35 days (range 9-60 days) after TAIC. Marked decrease in tumor size allowed one patient to receive breast-conserving surgery. There was no local recurrence in any patient. However, five patients (71%) experienced distant metastases. The 3-year disease free and overall survival were 0 and 71.4%, respectively. CONCLUSIONS: TAIC for locally advanced breast cancer is useful in reducing tumor size and achieving down-staging in a relatively short period, leading to an expanded surgical indication. |
| Authors | Kakuya Kitagawa, Koichiro Yamakado, Atsuhiro Nakatsuka, Naoshi Tanaka, Kaname Matsumura, Kan Takeda, Yoshifumi Kawarada
(Affiliation: Department of Radiology, Mie University School of Medicine, Tsu, Japan. kakuya at clin.medic.mie-u.ac.jp)
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| Journal | European journal of radiology
(Eur J Radiol)
Vol. 43
Issue 1
Pg. 31-6
(Jul 2002)
ISSN: 0720-048X Ireland |
| PMID | 12065118
(Publication Type: Journal Article)
|
| Chemical References |
- Antineoplastic Agents
- Doxorubicin
- Mitomycin
- Fluorouracil
- Epirubicin
|
| Topics |
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Breast
(pathology)
- Breast Neoplasms
(drug therapy, mortality, pathology, surgery)
- Combined Modality Therapy
- Doxorubicin
(administration & dosage, therapeutic use)
- Epirubicin
(administration & dosage, therapeutic use)
- Female
- Fluorouracil
(administration & dosage, therapeutic use)
- Humans
- Infusions, Intra-Arterial
- Middle Aged
- Mitomycin
(administration & dosage, therapeutic use)
- Neoplasm Staging
- Preoperative Care
- Survival Rate
|
