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Preoperative transcatheter arterial infusion chemotherapy for locally advanced breast cancer (stage IIIb) for down-staging and increase of resectability.

AbstractOBJECTIVES:
To evaluate the clinical usefulness of preoperative transcatheter arterial infusion chemotherapy (TAIC) for locally advanced breast cancer.
METHODS:
Seven patients with unresectable locally advanced breast cancer (stage IIIb) underwent TAIC percutaneously 1-3 times (mean, 1.7 times) until tumors became resectable. Anticancer drugs were injected into both the internal mammary and the distal subclavian arteries.
RESULTS:
There was no major complication related to the procedure. The mean tumor size was significantly decreased from 10.0+/-3.9 to 5.1+/-2.5 cm (P=0.0086). Skin and muscle invasions were improved in two patients (28%) and lymph nodes disappeared in one patient (14%). In two patients (28%), down-staging was achieved from stage IIIb to stage IIIa. All tumors turned into resectable, and mastectomy was performed with a mean period of 35 days (range 9-60 days) after TAIC. Marked decrease in tumor size allowed one patient to receive breast-conserving surgery. There was no local recurrence in any patient. However, five patients (71%) experienced distant metastases. The 3-year disease free and overall survival were 0 and 71.4%, respectively.
CONCLUSIONS:
TAIC for locally advanced breast cancer is useful in reducing tumor size and achieving down-staging in a relatively short period, leading to an expanded surgical indication.
AuthorsKakuya Kitagawa, Koichiro Yamakado, Atsuhiro Nakatsuka, Naoshi Tanaka, Kaname Matsumura, Kan Takeda, Yoshifumi Kawarada
JournalEuropean journal of radiology (Eur J Radiol) Vol. 43 Issue 1 Pg. 31-6 (Jul 2002) ISSN: 0720-048X [Print] Ireland
PMID12065118 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Epirubicin
  • Mitomycin
  • Doxorubicin
  • Fluorouracil
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Breast (pathology)
  • Breast Neoplasms (drug therapy, mortality, pathology, surgery)
  • Combined Modality Therapy
  • Doxorubicin (administration & dosage, therapeutic use)
  • Epirubicin (administration & dosage, therapeutic use)
  • Female
  • Fluorouracil (administration & dosage, therapeutic use)
  • Humans
  • Infusions, Intra-Arterial
  • Middle Aged
  • Mitomycin (administration & dosage, therapeutic use)
  • Neoplasm Staging
  • Preoperative Care
  • Survival Rate

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