Hydromorphone metabolites: isolation and identification from pooled urine samples of a cancer patient.

Abstract

1. Hydromorphone-3-glucuronide, dihydromorphine, dihydroisomorphine, dihydromorphine-3-glucuronide and dihydroisomorphine-3-glucuronide were isolated from a cancer patient's urine and identified as metabolites of hydromorphone by comparison with synthetic standards using LC/MS/MS with gradient elution. 2. The relative urinary recovery of dihydroisomorphine-3-glucuronide was estimated to be 17-fold higher than previously reported. 3. Three new metabolites, including hydromorphone-3-sulphate, norhydromorphone and nordihydroisomorphine, were tentatively identified.

• Authors: M Zheng, K M McErlane, M C Ong
• Journal: Xenobiotica; the fate of foreign compounds in biological systems (Xenobiotica) Vol. 32 Issue 5 Pg. 427-39 (May 2002) ISSN: 0049-8254 [Print] England
• PMID: 12065064 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Opioid
• Glucuronates
• Glucuronides
• hydromorphone-3-glucuronide
• Dihydromorphine
• Hydromorphone

Topics

• Analgesics, Opioid (chemistry, metabolism, urine)
• Chromatography, High Pressure Liquid
• Dihydromorphine (urine)
• Female
• Glucuronates (urine)
• Glucuronides (chemistry, urine)
• Humans
• Hydromorphone (analogs & derivatives, chemistry, metabolism, urine)
• Mass Spectrometry
• Molecular Structure
• Neoplasms (metabolism, urine)