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Significance of the molar ratio of branched-chain amino acids to tyrosine before hepatectomy.

AbstractBACKGROUND/AIMS:
To predict the degree of liver fibrosis and select a safe operative procedure, the correlation between liver fibrotic ratio and preoperative liver function variables were analyzed, and the significance of the molar ratio of branched-chain amino acids to tyrosine determined preoperatively was investigated.
METHODOLOGY:
Forty-four patients with hepatectomy were enrolled in this study. Liver tissue specimens excised from the patients were stained by Azan-Mallory's method. The liver fibrotic ratio was measured using an Image Cytometer. The correlation between liver fibrotic ratio and preoperative liver function values, including the serum level of branched-chain amino acids to tyrosine, were determined.
RESULTS:
The degrees of liver fibrosis (normal group, 1.4 +/- 0.7%; chronic hepatitis group, 4.5 +/- 2.8%; cirrhosis group, 8.4 +/- 2.4%) correlated significantly with preoperative liver function values such as branched-chain amino acids to tyrosine, hepaplastin test, type IV collagen 7s domain, total bilirubin, indocyanine green clearance retention rate at fifteen minutes, and platelet count. The serum level of branched-chain amino acids to tyrosine showed the most-significant correlation with the degree of liver fibrosis.
CONCLUSIONS:
The serum level of branched-chain amino acids to tyrosine correlates well with the degree of liver fibrosis, and this value is a useful preoperative parameter for predicting the degree of liver fibrosis and for selecting a safe operative procedure.
AuthorsToshihiko Kohashi, Toshiyuki Itamoto, Koji Katayama, Shigeru Katayama, Hiroshi Hino, Hideki Nakahara, Hirotaka Tashiro, Toshimasa Asahara
JournalHepato-gastroenterology (Hepatogastroenterology) 2002 May-Jun Vol. 49 Issue 45 Pg. 774-7 ISSN: 0172-6390 [Print] Greece
PMID12063988 (Publication Type: Journal Article)
Chemical References
  • Amino Acids, Branched-Chain
  • Tyrosine
Topics
  • Adolescent
  • Adult
  • Aged
  • Amino Acids, Branched-Chain (blood)
  • Carcinoma, Hepatocellular (blood, pathology, surgery)
  • Female
  • Hepatectomy
  • Humans
  • Liver Cirrhosis (blood, pathology)
  • Liver Function Tests
  • Liver Neoplasms (blood, pathology, surgery)
  • Male
  • Middle Aged
  • Tyrosine (blood)

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