Study on the amount of binding of anti-tumor metal complexes to different target sites of dGMP using trans-[en(2)Os(eta2-H(2))(CF(3)SO(3))](CF(3)SO(3)) in a competitive mode.

Abstract

In order to investigate the binding sites and the amount of binding of a number of anti-tumor metal complexes (cisplatin, Cp(2)TiCl(2) and (CH(3))(2)SnCl(2)) to target molecule DNA mononucleotides in aqueous solution, a 1H NMR recognition probe, trans-[en(2)Os(eta2-H(2))(CF(3)SO(3))](CF(3)SO(3)), was used in a competitive mode. The minimum percentages of binding of anti-tumor metal complexes to different sites of dGMP were also determined.

• Authors: Pin Yang, Xiang-Li Meng, Li-Jun Yue, Yi-Bin Wei
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 89 Issue 3-4 Pg. 248-54 (Apr 28 2002) ISSN: 0162-0134 [Print] United States
• PMID: 12062129 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Deoxyguanine Nucleotides
• Metals
• Molecular Probes
• 2'-deoxyguanosine 5'-phosphate
• Cisplatin

Topics

• Antineoplastic Agents (metabolism)
• Binding, Competitive
• Cisplatin (analogs & derivatives, metabolism)
• Deoxyguanine Nucleotides (metabolism)
• Magnetic Resonance Spectroscopy
• Metals (metabolism)
• Molecular Probes (chemistry, metabolism)
• Time Factors