Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and prednisone.

Abstract

BACKGROUND:

Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin.

METHODS:

A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia.

RESULTS:

Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission.

CONCLUSION:

This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia.

• Authors: P R Criado, C Vasconcellos, J R Pegas, L F Lopes, C F Ramos, A J Tebcherani, N Y S Valente
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 13 Issue 2 Pg. 87-9 (Jun 2002) ISSN: 0954-6634 [Print] England
• PMID: 12060508 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Melphalan
• Prednisone

Topics

• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Diagnosis, Differential
• Drug Therapy, Combination
• Female
• Histiocytosis (complications, diagnosis, drug therapy)
• Humans
• Melphalan (therapeutic use)
• Necrobiosis Lipoidica (complications, diagnosis, drug therapy)
• Paraproteinemias (complications, diagnosis, drug therapy)
• Prednisone (therapeutic use)