HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibitory effect of xanthomicrol and 3 alpha-angeloyloxy-2 alpha-hydroxy-13,14Z-dehydrocativic acid from Brickellia paniculata on the contractility of guinea-pig ileum.

Abstract
Chemical fractionation of Brickellia paniculata methanolic extract by monitoring its inhibitory effect on K(+)-induced contraction in guinea-pig ileum in vitro led to the isolation of 5,4'-dihydroxy-6,7,8-trimethoxyflavone (xanthomicrol) and the labdane-diterpene 3 alpha-angeloyloxy-2 alpha-hydroxy-13,14 Z-dehydrocativic acid (AAHDD). Both compounds inhibited the tonic contraction the effect being highly potent when a mixture in a proportion of 3 : 1 (xanthomicrol/AAHDD) was assayed. The phasic component of the contractile response with K(+) was also reduced by the compounds. Xanthomicrol depressed the spasms induced with ACh, Hist, and BaCl(2) and its effect on Ca (2+) concentration-response curve showed a type of non-surmountable calcium blocking action; unlike the flavonoid, AAHDD produced a parallel rightward shift of the concentration-response curve to calcium, suggesting a competitive antagonism with an estimated pA(2) of 4.66. Obtained results support, in part, the popular use of B. paniculata as a spasmolytic remedy.
AuthorsMariana Meckes, Fernando Calzada, Daniel Paz, Jaime Rodríguez, Héctor Ponce-Monter
JournalPlanta medica (Planta Med) Vol. 68 Issue 5 Pg. 467-9 (May 2002) ISSN: 0032-0943 [Print] Germany
PMID12058331 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • 3-angeloyloxy-2-hydroxy-13,14-dehydrocativic acid
  • Barium Compounds
  • Chlorides
  • Diterpenes
  • Flavones
  • Flavonoids
  • Naphthalenes
  • Pentanoic Acids
  • Plant Extracts
  • labdane
  • barium chloride
  • xanthomicrol
  • Potassium Chloride
  • Histamine
  • Acetylcholine
  • Calcium
Topics
  • Acetylcholine (pharmacology)
  • Animals
  • Asteraceae
  • Barium Compounds (pharmacology)
  • Calcium (pharmacology)
  • Chlorides (pharmacology)
  • Diterpenes (pharmacology)
  • Flavones
  • Flavonoids (chemistry, isolation & purification, pharmacology)
  • Guinea Pigs
  • Histamine (pharmacology)
  • Ileum (drug effects)
  • In Vitro Techniques
  • Muscle Contraction (drug effects)
  • Muscle, Smooth (drug effects)
  • Naphthalenes (chemistry, isolation & purification, pharmacology)
  • Pentanoic Acids (chemistry, isolation & purification, pharmacology)
  • Plant Extracts (chemistry, isolation & purification, pharmacology)
  • Potassium Chloride (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: