Antiproliferative amaryllidaceae alkaloids isolated from the bulbs of Sprekelia formosissima and Hymenocallis x festalis.

Seven alkaloids were isolated from Sprekelia formosissima, and five from Hymenocallis x festalis. Tazettine, lycorine, haemanthidine and haemanthamine were evaluated for antiproliferative and multidrug resistance (mdr) reversing activity on mouse lymphoma cells. Lycorine, haemanthidine and haemanthamine displayed pronounced cell growth inhibitory activities against both drug-sensitive and drug-resistant cell lines, but did not significantly inhibit mdr-1 p-glycoprotein. Thus, the tested alkaloids are apparently not substrates for the mdr efflux pump. Assays for interactions with DNA and RNA revealed that the antiproliferative effects of lycorine and haemanthamine result from their complex formation with RNA.
AuthorsJudit Hohmann, Peter Forgo, Joseph Molnár, Krisztina Wolfard, Annamária Molnár, Theresia Thalhammer, Imre Máthé, Derek Sharples
JournalPlanta medica (Planta Med) Vol. 68 Issue 5 Pg. 454-7 (May 2002) ISSN: 0032-0943 [Print] Germany
PMID12058326 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • 3-epimacronine
  • 8-demethylmaritidine
  • Alkaloids
  • Amaryllidaceae Alkaloids
  • Aniline Compounds
  • Antineoplastic Agents, Phytogenic
  • Dioxoles
  • Phenanthridines
  • pretazettine
  • ismine
  • trispheridine
  • hemanthidine
  • hemanthamine
  • tazettine
  • DNA
  • RNA, Transfer
  • Verapamil
  • lycorine
  • Alkaloids (chemistry, isolation & purification, pharmacology)
  • Amaryllidaceae Alkaloids
  • Angiosperms
  • Aniline Compounds (chemistry, isolation & purification, pharmacology)
  • Animals
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • DNA (chemistry, drug effects)
  • Dioxoles (chemistry, isolation & purification, pharmacology)
  • Drug Resistance, Multiple
  • Leukemia L5178 (drug therapy, pathology)
  • Mice
  • Molecular Structure
  • Nucleic Acid Denaturation (drug effects)
  • Phenanthridines (chemistry, isolation & purification, pharmacology)
  • Plant Stems (chemistry)
  • RNA, Transfer (chemistry, drug effects)
  • Tumor Cells, Cultured (drug effects, metabolism)
  • Verapamil (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: