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The antiandrogenic effect of flutamide improves uterine perfusion in women with polycystic ovary syndrome.

AbstractOBJECTIVE:
To evaluate whether, by blocking androgen action, flutamide can decrease and normalize vascular resistance in the uterine artery in patients with polycystic ovary syndrome (PCOS).
DESIGN:
Prospective and controlled study.
SETTING:
Endocrinological Centre of the Department of Obstetrics and Gynecology of the University of Cagliari, Italy.
PATIENT(S):
Twenty-two patients with PCOS were enrolled in the study and randomly assigned to one of the following two treatments for 3 months: oral administration of flutamide (250 mg twice daily) or placebo.
INTERVENTION(S):
Doppler flow measurement of the uterine artery and serum hormone concentration determination during the early follicular phase of the menstrual cycle before treatment and during the third month of treatment.
MAIN OUTCOME MEASURE(S):
Pulsatility index (PI) of the uterine artery before and during treatment.
RESULT(S):
The PI of the uterine artery decreased significantly during treatment. No difference was found in patients treated with placebo. Correlation was found only between the PI values of the uterine artery and DHEAS.
CONCLUSION(S):
The low uterine perfusion that characterizes patients with PCOS can be improved by the antiandrogenic effect of flutamide.
AuthorsSilvia Ajossa, Stefano Guerriero, Anna Maria Paoletti, Marisa Orrù, Gian Benedetto Melis
JournalFertility and sterility (Fertil Steril) Vol. 77 Issue 6 Pg. 1136-40 (Jun 2002) ISSN: 0015-0282 [Print] United States
PMID12057718 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Androgen Antagonists
  • Placebos
  • Dehydroepiandrosterone Sulfate
  • Flutamide
Topics
  • Administration, Oral
  • Adult
  • Androgen Antagonists (therapeutic use)
  • Arteries (physiopathology, ultrasonography)
  • Dehydroepiandrosterone Sulfate (blood)
  • Female
  • Flutamide (administration & dosage, therapeutic use)
  • Humans
  • Placebos
  • Polycystic Ovary Syndrome (drug therapy, physiopathology)
  • Pulse
  • Regional Blood Flow (drug effects)
  • Uterus (blood supply)

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