[Ototoxic effect and its prevention in administration of cisplatin].

Abstract

Short-latent acoustic evoked potentials were registered in examination of hearing function in guinea pigs given platinum compounds. A protective action of thiol compounds (sodium thiosulfate and unitiol) was tried in relation to hypoacusis induced by cisplatinum.

• Authors: M R Bogomil'skiĭ, I N D'iakonova, V G Poliakov, I V Rakhmanova, O A Stakhovskaia, A M Tikhomirov
• Journal: Vestnik otorinolaringologii (Vestn Otorinolaringol) Issue 2 Pg. 7-10 ( 2002) ISSN: 0042-4668 [Print] Russia (Federation)
• Vernacular Title: Ototoksicheskoe deĭstvie tsisplatina i vozmozhnosti ego profilaktiki.
• PMID: 12056168 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Chelating Agents
• Thiosulfates
• Unithiol
• sodium thiosulfate
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (adverse effects)
• Chelating Agents (administration & dosage, therapeutic use)
• Cisplatin (adverse effects)
• Female
• Guinea Pigs
• Hearing Disorders (chemically induced, prevention & control)
• Thiosulfates (administration & dosage, therapeutic use)
• Unithiol (administration & dosage, therapeutic use)