Azaftig stimulates in vitro lipolysis by rodent and human adipocytes.

Abstract

Azaftig is an urinary proteoglycan present in some cancer and AIDS patients experiencing weight loss. Administration of azaftig to mice results in weight loss that is associated with loss of fat depot. So far, very little is known about the mechanism underlying loss of fat depot in mice or weight loss in patients excreting azaftig. Augmentation of lipolysis may be one mechanism that can cause reduction of fat depot. Therefore, the present study was designed to examine the effect of azaftig on lipolysis by adipocytes derived from obese rats and humans. Results show a dose-dependent potentiation of lipolysis by azaftig in both rat and human adipocytes.

• Authors: Julio E Figueroa 2nd, Parakat Vijayagopal, Chandan Prasad
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 293 Issue 2 Pg. 847-9 (May 03 2002) ISSN: 0006-291X [Print] United States
• PMID: 12054548 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Elsevier Science (USA).

Chemical References

• Proteoglycans
• azaftig

Topics

• Adipocytes (drug effects, metabolism)
• Animals
• Cells, Cultured
• Dose-Response Relationship, Drug
• Female
• Humans
• Lipolysis (drug effects)
• Obesity (metabolism, urine)
• Proteoglycans (pharmacology)
• Rats
• Rats, Zucker