Abstract | OBJECTIVE: METHODS: RESULTS: Fifty-seven patients received at least two courses of treatment and are evaluable for response. Twenty-six patients (46%) achieved an objective response, including 19% complete and 27% partial responses. The median duration of response was 11.5 months and the median time to progression and survival for all patients were 8.3 and 18.6 months, respectively. Patients with excellent performance status, with disease recurrence outside the radiation field, and with nonsquamous tumors had the highest response rate and best survival. Some degree of neurotoxicity occurred in 44% of patients. Grade 3 or 4 toxicity included granulocytopenia in 26% of patients, anemia in 13%, thrombocytopenia in 7%, and neurotoxicity in 3%. CONCLUSION: The ITP regimen is relatively well tolerated and moderately active in patients with metastatic carcinoma of the uterine cervix. Patients more likely to benefit are those with nonsquamous histology, with excellent performance status, and with disease recurrence outside the radiation field.
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Authors | Meletios A Dimopoulos, Christos A Papadimitriou, Kyrillos Sarris, Gerassimos Aravantinos, Charalambos Kalofonos, Dimitra Gika, Georgios M Gourgoulis, Eleni Efstathiou, Dimosthenis Skarlos, Dimitrios Bafaloukos |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 85
Issue 3
Pg. 476-82
(Jun 2002)
ISSN: 0090-8258 [Print] United States |
PMID | 12051877
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study)
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Chemical References |
- Paclitaxel
- Cisplatin
- Ifosfamide
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Cisplatin
(administration & dosage, adverse effects)
- Disease Progression
- Drug Administration Schedule
- Female
- Humans
- Ifosfamide
(administration & dosage, adverse effects)
- Infusions, Intravenous
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
(drug therapy, pathology)
- Outpatients
- Paclitaxel
(administration & dosage, adverse effects)
- Prospective Studies
- Survival Rate
- Uterine Cervical Neoplasms
(drug therapy, pathology)
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