[Risk factors of transient cerebral ischemic episodes: hyperfibrinogenemia and carotid histopathology].

Abstract

Risk factors may play a fundamental role in the evolution from a stable to a vulnerable plaque. In particular, the hyperfibrinogenemia, independently from other risk factors, influences the natural history of cerebrovascular disease modifying the histologic composition of atherosclerotic plaques and precipitates carotid thrombosis resulting from rupture of the plaque. Determination of plasma fibrinogen may help to identify a subset of patients at high risk for a rapid progression of carotid atherosclerosis and related clinical events. We suggest that these patients may benefit of an earlier surgical intervention even if the degree of carotid stenosis is not severe.

• Authors: Luigi Giusto Spagnoli, Alessandro Mauriello, Stefano Fratoni, Lucia Anemona, Elena Bonanno
• Journal: Recenti progressi in medicina (Recenti Prog Med) Vol. 93 Issue 5 Pg. 318-21 (May 2002) ISSN: 0034-1193 [Print] Italy
• Vernacular Title: Fattori di rischio degli episodi ischemici cerebrali transitori: iperfibrinogenemia e istopatologia carotidea.
• PMID: 12050916 (Publication Type: Editorial, English Abstract, Review)

Chemical References

• Fibrinogen

Topics

• Arteriosclerosis (complications)
• Carotid Artery Diseases (complications)
• Fibrinogen (metabolism)
• Hematologic Diseases (complications)
• Humans
• Ischemic Attack, Transient (etiology)
• Risk Factors