Abstract | PURPOSE: METHODS: Eighteen 6.0-mm polyester grafts (length, 5.0 cm) were implanted in dogs end-to-end into the infrarenal aorta. The dogs were divided into four groups as a function of type of prosthesis implanted. The dogs in groups I (n = 3) and II (n = 3) received control gelatin-sealed or collagen-coated polyester prostheses, respectively. In group III (n = 6), the dogs received rifampin-bonded gelatin-sealed polyester prostheses. In group IV (n = 6), the dogs received silver/ collagen-coated polyester prostheses. Two days after implantation, the grafts were challenged with 6 x 10(9) Staphylococcus aureus intravenously. One week after implantation, the grafts were harvested with sterile technique. Quantitative cultures were obtained from all the harvested grafts. The results were expressed as colony-forming units per cm(2) of graft material. Bacteriologic study was also performed on various tissue samples. The chi(2) test was used to compare the culture proven infection of control and antimicrobial grafts. RESULTS: All the control grafts were infected with S aureus at the time of removal. Five of the six silver/ collagen-coated grafts were infected, whereas none of the six rifampin-bonded gelatin-sealed grafts grew S aureus (P <.01). There was no significant difference in the number of positive culture results of organ samples between the different groups of dogs. CONCLUSION:
|
Authors | Olivier A Goëau-Brissonnière, Dominique Fabre, Véronique Leflon-Guibout, Isabelle Di Centa, Marie-Hélène Nicolas-Chanoine, Marc Coggia |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 35
Issue 6
Pg. 1260-3
(Jun 2002)
ISSN: 0741-5214 [Print] United States |
PMID | 12042739
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Acetates
- Biocompatible Materials
- Polyesters
- Silver Compounds
- silver acetate
- Rifampin
|
Topics |
- Acetates
(administration & dosage)
- Animals
- Biocompatible Materials
- Blood Vessel Prosthesis
- Blood Vessel Prosthesis Implantation
- Dogs
- Polyesters
- Prosthesis-Related Infections
(prevention & control)
- Rifampin
(administration & dosage)
- Silver Compounds
(administration & dosage)
- Staphylococcal Infections
(prevention & control)
|