8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.

Abstract

A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).

• Authors: George M Buckley, Nicola Cooper, Hazel J Dyke, Fiona P Galleway, Lewis Gowers, Alan F Haughan, Hannah J Kendall, Christopher Lowe, Robert Maxey, John G Montana, Robert Naylor, Janet Oxford, Joanna C Peake, C Louise Picken, Karen A Runcie, Verity Sabin, Andrew Sharpe, Julie B H Warneck
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 12 Issue 12 Pg. 1613-5 (Jun 17 2002) ISSN: 0960-894X [Print] England
• PMID: 12039574 (Publication Type: Journal Article)

Chemical References

• Amides
• Anti-Asthmatic Agents
• Phosphodiesterase Inhibitors
• 3',5'-Cyclic-AMP Phosphodiesterases
• Cyclic Nucleotide Phosphodiesterases, Type 4

Topics

• 3',5'-Cyclic-AMP Phosphodiesterases (antagonists & inhibitors)
• Amides (pharmacology, therapeutic use)
• Anti-Asthmatic Agents (pharmacology, therapeutic use)
• Asthma (drug therapy)
• Cyclic Nucleotide Phosphodiesterases, Type 4
• Humans
• Phosphodiesterase Inhibitors (pharmacology, therapeutic use)