Abstract |
This study aimed at determining the prevalence of INK4 deletions and their impact on outcome in 125 children with acute lymphoblastic leukemia (ALL) at first relapse using real-time quantitative polymerase chain reaction. Patients were enrolled into relapse trials ALL-REZ BFM (ALL-Relapse Berlin-Frankfurt-Münster) 90 and 96. The prevalence of p16(INK4a) and p15(INK4b) homozygous deletions was 35% (44 of 125) and 30% (38 of 125), respectively. A highly significant association of both gene deletions was found with the 2 major adverse prognostic factors known for relapsed childhood ALL: T-cell immunophenotype and first remission duration. There was no correlation between INK4 deletions and probability of event-free survival. These findings argue against an independent prognostic role of INK4 deletions in relapsed childhood ALL.
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Authors | Hagen Graf Einsiedel, Tillmann Taube, Reinhard Hartmann, Sven Wellmann, Georg Seifert, Günter Henze, Karl Seeger |
Journal | Blood
(Blood)
Vol. 99
Issue 12
Pg. 4629-31
(Jun 15 2002)
ISSN: 0006-4971 [Print] United States |
PMID | 12036898
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CDKN2B protein, human
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Tumor Suppressor Proteins
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Topics |
- Bone Marrow Cells
(pathology)
- Cell Cycle Proteins
(genetics)
- Child
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
(genetics)
- Disease-Free Survival
- Female
- Gene Deletion
- Humans
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(epidemiology, genetics, pathology)
- Prevalence
- Prognosis
- Recurrence
- Retrospective Studies
- Survival Analysis
- Tumor Suppressor Proteins
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