Abstract | PURPOSE: METHODS:
PEO-b-PHSA with three levels of stearic acid substitution were synthesized and used to encapsulate AmB by a solvent evaporation method. Size exclusion chromatography and UV spectroscopy were used to confirm and measure levels of encapsulated AmB. The hemolytic activity of encapsulated AmB toward human red blood cells and its minimum inhibitory concentration against Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans were obtained and compared to AmB alone. RESULTS: CONCLUSIONS:
PEO-b-PHSA micelles with a high level of stearic acid side chain substitution can effectively solubilize AmB, reduce its hemolytic activity yet retain its potent antifungal effects.
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Authors | Afsaneh Lavasanifar, John Samuel, Saeed Sattari, Glen S Kwon |
Journal | Pharmaceutical research
(Pharm Res)
Vol. 19
Issue 4
Pg. 418-22
(Apr 2002)
ISSN: 0724-8741 [Print] United States |
PMID | 12033373
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Micelles
- Polymers
- Amphotericin B
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Topics |
- Amphotericin B
(administration & dosage, chemistry)
- Drug Compounding
(methods)
- Drug Delivery Systems
(methods)
- Hemolysis
(drug effects)
- Humans
- Micelles
- Polymers
(administration & dosage, chemistry)
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