Abstract | BACKGROUND: METHODS: RESULTS: Diabetic patients have significant increase of SOD activity, of TBARS concentration (concomitant with low levels of unsaturated fatty acids) and significant decrease of GSH and alpha-tocopherol. NIDDM have significantly lower levels of GSH and higher levels of TBARS compared to IDDM. ITDM2 values are intermediate between IDDM and NIDDM but are far from reaching those of IDDM. CONCLUSION: Diabetic patients undergo an important oxidative stress that is nearly corrected for IDDM, but only partially improved for ITDM2, although length of insulin treatment and HbA1c values are similar, suggesting metabolic differences between the two types of diabetes.
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Authors | Ilham Seghrouchni, Jocelyne Drai, Edith Bannier, Joël Rivière, Pascale Calmard, Isabelle Garcia, Jacques Orgiazzi, André Revol |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 321
Issue 1-2
Pg. 89-96
(Jul 2002)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 12031597
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Insulin
- Thiobarbituric Acid Reactive Substances
- Glutathione
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Topics |
- Adult
- Aged
- Antioxidants
(metabolism)
- Diabetes Mellitus, Type 1
(enzymology, metabolism)
- Diabetes Mellitus, Type 2
(drug therapy, enzymology, metabolism)
- Female
- Glutathione
(metabolism)
- Humans
- Insulin
(pharmacology, therapeutic use)
- Male
- Middle Aged
- Oxidative Stress
(drug effects)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Treatment Outcome
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