Abstract | OBJECTIVES: METHODS: RESULTS: Only in the patients with FH was the lumbar spine bone density lower than in the controls (P <0.001). Also, only the patients with FH had higher bone alkaline phosphatase and urinary hydroxyproline levels than the control group (P <0.005 and <0.015, respectively). The blood pH levels were lower, even though within the normal range, in the hypercalciuric patients than in the controls (P <0.01). There was a negative correlation between the urinary hydroxyproline level and lumbar spine and femoral neck density in patients with FH (P <0.001 and <0.005, respectively), and the blood pH correlated positively with the lumbar spine bone density. CONCLUSIONS: Altered bone metabolism and overall bone loss were found only in the patients with FH. Overloading of acid valences, perhaps of dietary origin, could be the pathogenic factor responsible.
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Authors | A Tasca, A Cacciola, P Ferrarese, E Ioverno, E Visonà, C Bernardi, M Nobile, S Giannini |
Journal | Urology
(Urology)
Vol. 59
Issue 6
Pg. 865-9; discussion 869
(Jun 2002)
ISSN: 1527-9995 [Electronic] United States |
PMID | 12031370
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alkaline Phosphatase
- Hydroxyproline
- Calcium
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Topics |
- Adult
- Alkaline Phosphatase
(urine)
- Bone Density
- Bone Resorption
(complications, metabolism, urine)
- Calcium
(metabolism, urine)
- Calcium Metabolism Disorders
(complications, metabolism, urine)
- Female
- Femur
(metabolism, physiology)
- Humans
- Hydrogen-Ion Concentration
- Hydroxyproline
(urine)
- Kidney Calculi
(chemistry, complications, metabolism)
- Male
- Middle Aged
- Spine
(metabolism, physiology)
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