Abstract | OBJECTIVE:
Proteases are involved in the invasion and metastasis of carcinoma cells. In vivo, oral carcinoma cells easily invade the bone tissue and metastasize to the submandibular and neck lymph nodes. Cathepsin expression has been shown in some neoplastic tissues and serves as a prognostic indicator. The purpose of this study was to investigate the relationship between clinicopathohistologic grades and cathepsin expressions in oral squamous cell carcinoma and to investigate which cathepsin provides prognostic information for patients with oral carcinoma. STUDY DESIGN: RESULTS:
Cathepsins B, H, L, and D were positive in every case. Although the labeling indices for cathepsins B (CB-LI), H (CH-LI), and D (CD-LI) for the cancer cases showed significant differences from those of controls, cathepsin L (CL-LI) of cancer cases showed no difference from that of controls (P <.05). A close correlation was found between CD-LI and T categories of TNM classification (P <.05), and between CD-LI and PCNA-LI (P <.05). Furthermore, a close correlation was found between CD-LI and N categories in TNM classification (P <.05). Pathologically, a close correlation was found between CB-LI or CD-LI and the pattern and/or stage of invasion (P <.05). CONCLUSION:
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Authors | Goro Kawasaki, Yuzo Kato, Akio Mizuno |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 93
Issue 4
Pg. 446-54
(Apr 2002)
ISSN: 1079-2104 [Print] United States |
PMID | 12029284
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Enzyme Precursors
- Proliferating Cell Nuclear Antigen
- Cathepsins
- Cysteine Endopeptidases
- Cathepsin B
- CTSL protein, human
- Cathepsin L
- CTSH protein, human
- Cathepsin H
- Cathepsin D
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Biomarkers, Tumor
(analysis, blood, genetics)
- Carcinoma, Squamous Cell
(enzymology, pathology, secondary)
- Cathepsin B
(analysis, blood, genetics)
- Cathepsin D
(analysis, blood, genetics)
- Cathepsin H
- Cathepsin L
- Cathepsins
(analysis, blood, genetics)
- Cysteine Endopeptidases
(analysis, blood, genetics)
- Enzyme Precursors
(analysis, blood, genetics)
- Female
- Gene Expression Regulation, Enzymologic
(genetics)
- Gene Expression Regulation, Neoplastic
(genetics)
- Gingival Neoplasms
(enzymology, pathology)
- Humans
- Linear Models
- Male
- Middle Aged
- Mouth Floor
(pathology)
- Mouth Neoplasms
(enzymology, pathology)
- Neoplasm Invasiveness
- Neoplasm Staging
- Prognosis
- Proliferating Cell Nuclear Antigen
(analysis)
- Statistics as Topic
- Survival Rate
- Tongue Neoplasms
(enzymology, pathology)
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