Abstract |
A preliminary study was conducted to detect significant differences between the inflammatory cytokines network recorded in mild and severe preeclampsia compared with normal pregnancy. 36 patients were divided in two groups: (NP) normal pregnancy and (SPH) Severe Preeclampsia and HELLP syndrome. Inflammatory cytokines (IL 6, TNF, IL 10), Antithrombin III (AT III), Protein C (PC) and Tissue Factor Pathway Inhibitor ( TFPI) plasma level and Organ Disfunction modified Score (ODS) were recorded. Results shows a difference (P<0,05 ) for AT III and other markers levels in the two groups and, inside of the SPH group, between Severe preeclampsia patients and HELLP syndrome patients. A correlation was found between coagulation natural inhibitors, specially antithrombin III, and the clinical scores. Performing a Caesarean section did not change these results. Based on results of the study we have designed a monitoring and a treatment protocol in our obstetric and general ICU. A multicentric study is now ongoing to validate the preliminary data on the substitutive treatment with AT III.
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Authors | S Mangione, A Giarratano |
Journal | Minerva anestesiologica
(Minerva Anestesiol)
Vol. 68
Issue 5
Pg. 449-53
(May 2002)
ISSN: 0375-9393 [Print] Italy |
PMID | 12029262
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Biomarkers
- Serine Proteinase Inhibitors
- Antithrombin III
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Topics |
- Adolescent
- Adult
- Antithrombin III
(therapeutic use)
- Biomarkers
- Critical Care
- Female
- Humans
- Obstetric Labor Complications
(diagnosis, drug therapy)
- Pre-Eclampsia
(drug therapy)
- Pregnancy
- Serine Proteinase Inhibitors
(therapeutic use)
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