[Effect of combined application of carboxylin and sodium citrate on the restoration of blood proteins under conditions of experimental anemia].

Abstract

Under the effect of combined application of "carboxylin"--the preparation stimulating the processes of CO2 fixation in the tissues and sodium citrate--one of the most important intermediates of the cycle of citric acid, the processes of the erythrocytic and protein composition restoration in the peripheral blood were studied under conditions of posthemorrhagic anemia in rats. It is established that under the effect of combined application of "carboxylin" with sodium citrate there is observed rapid normalization of peripheral blood indexes--erythrocytes, hemoglobin, hematocrit number, total proteins, albumin and globulins of blood serum. All mentioned evidences for a stimulating effect of the given preparations on the biosynthetic processes in the organism and for possibility of blood regeneration acceleration under conditions of posthemorrhagic anemia.

• Authors: M F Guly, L I Holubeva
• Journal: Ukrains'kyi biokhimichnyi zhurnal (Ukr Biokhim Zh) 1975 Nov-Dec Vol. 47 Issue 6 Pg. 696-700 ISSN: 0041-610X [Print] Ukraine
• PMID: 1202703 (Publication Type: Journal Article)

Chemical References

• Bicarbonates
• Blood Proteins
• Citrates
• Drug Combinations
• Metals
• Quaternary Ammonium Compounds
• Carbon Dioxide
• ammonium, magnesium, manganese, sodium bicarbonate, zinc sulfate drug combination
• Sodium Bicarbonate

Topics

• Anemia (blood, chemically induced, metabolism)
• Animals
• Bicarbonates (pharmacology)
• Blood Proteins (biosynthesis, metabolism)
• Carbon Dioxide (metabolism)
• Citrates (pharmacology)
• Citric Acid Cycle (drug effects)
• Drug Combinations
• Erythrocytes (drug effects, metabolism)
• Metals (pharmacology)
• Organ Specificity
• Quaternary Ammonium Compounds (pharmacology)
• Rats
• Sodium Bicarbonate