Abstract |
The ability of a series of new 17 alpha-Hydroxyprogesteron derivatives (acetomepregnol, AMOL phenyl propyoate, butagest) in preventing the prostaglandin-induced preterm labor was experimentally studied in mice. It was found that all the synthetic gestagens studied, especially butagest, maintained pregnancy in all test animals on the model of enzaprost F induced abortion. The proposed progestogens can be used to prevent abortion in pregnancies in cases of risk from diseases connected with excess prostaglandin secretion.
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Authors | N I Tapil'skaia, M A Petrosian, E A Lesik |
Journal | Eksperimental'naia i klinicheskaia farmakologiia
(Eksp Klin Farmakol)
2002 Jan-Feb
Vol. 65
Issue 1
Pg. 44-5
ISSN: 0869-2092 [Print] Russia (Federation) |
Vernacular Title | Terapevticheskaia aktivnost' novykh proizvodnykh 17al'fa-oksiprogesterona pri nevynashivanii beremennosti v éksperimente. |
PMID | 12025785
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Abortifacient Agents, Nonsteroidal
- progesterone 17 alpha-hydroperoxide
- Progesterone
- Dinoprost
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Topics |
- Abortifacient Agents, Nonsteroidal
- Abortion, Induced
- Animals
- Dinoprost
- Female
- Mice
- Obstetric Labor, Premature
(chemically induced, prevention & control)
- Pregnancy
- Progesterone
(analogs & derivatives, therapeutic use)
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