[Therapeutic efficacy of novel 17alpha-hydroxyprogesterone derivatives in experimental preterm labor].

Abstract	The ability of a series of new 17 alpha-Hydroxyprogesteron derivatives (acetomepregnol, AMOL phenyl propyoate, butagest) in preventing the prostaglandin-induced preterm labor was experimentally studied in mice. It was found that all the synthetic gestagens studied, especially butagest, maintained pregnancy in all test animals on the model of enzaprost F induced abortion. The proposed progestogens can be used to prevent abortion in pregnancies in cases of risk from diseases connected with excess prostaglandin secretion.
Authors	N I Tapil'skaia, M A Petrosian, E A Lesik
Journal	Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2002 Jan-Feb Vol. 65 Issue 1 Pg. 44-5 ISSN: 0869-2092 [Print] Russia (Federation)
Vernacular Title	Terapevticheskaia aktivnost' novykh proizvodnykh 17al'fa-oksiprogesterona pri nevynashivanii beremennosti v éksperimente.
PMID	12025785 (Publication Type: English Abstract, Journal Article)
Chemical References	Abortifacient Agents, Nonsteroidal progesterone 17 alpha-hydroperoxide Progesterone Dinoprost
Topics	Abortifacient Agents, Nonsteroidal Abortion, Induced Animals Dinoprost Female Mice Obstetric Labor, Premature (chemically induced, prevention & control) Pregnancy Progesterone (analogs & derivatives, therapeutic use)

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