[Acanthamoeba keratitis, a possible dibromo propamidine isethionate resistance].

Abstract

PURPOSE/METHOD:

To point out that acanthamoeba keratitis can show therapeutical resistance to dibrome propamidine isethionate (Brolene). We have a late diagnosis case of corneal melting on a bilateral acanthamoeba keratitis.

RESULTS/CONCLUSION:

We performed corneal graft in one eye and found histopathological evidence of acanthamoeba. There was relapse in the graft in spite of Brolene treatment and good results when we changed to polyhidroxy methylbigunide (PHMB). In case of therapeutical Brolene resistance, PHMB can be an adequate alternative (Arch Soc Esp Oftalmol 2002; 77: 279-282).

• Authors: M Vaquero Ruano, J L Encinas Martín, S Ramón Y Cajal, C Cajigal Morales
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 77 Issue 5 Pg. 279-81 (May 2002) ISSN: 0365-6691 [Print] Spain
• Vernacular Title: Queratitis por acantamoeba, posible resistencia al dibromo propamidin isetionato.
• PMID: 12023748 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antiprotozoal Agents
• Benzamidines
• propamidine isethionate

Topics

• Acanthamoeba Keratitis (drug therapy)
• Adult
• Antiprotozoal Agents (therapeutic use)
• Benzamidines (therapeutic use)
• Drug Resistance
• Humans
• Male