Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery.

Abstract

BACKGROUND:

Recent data indicate that pneumoperitoneal carbondioxide (CO2) insufflation impairs hepatic macro- and microcirculation. Whether dopamine and endothelin-1 (ET-1) antagonists might restore liver blood during laparoscopic surgery has not yet been investigated.

METHODS:

For this study, 30 male WAG/Rij rats were randomized into two groups to obtain pneumoperitoneum with CO2 (n=15) or helium (n = 15). All the animals were implanted with a polyethylene-50 cannula into the right vena jugularis and a Doppler ultrasound flow probe around the portal vein. In each group, the rats were administered dopamine (n = 5); JKC-10, JKC-301, which is a selective endothelin-1 (ET-1) antagonist (n = 5), or sodium chloride as a control (n = 5). Portal blood flow was measured during intraabdominal pressures 2 to 12 mmHg. Data were analyzed using the Kruskal-Wallis h-test.

RESULTS:

The application of dopamine and ET-1 antagonists significantly improved portal blood flow over that of the control animals (p <0.05). No significant differences were found between CO2 and helium insufflation (P > 0.05).

CONCLUSIONS:

Dopamine and ET-1 antagonism restore portal blood flow during laparoscopic surgery independently of the insufflation gas. Whether improved hepatic perfusion might have beneficial effects on liver function needs further investigation.

• Authors: Z-G Kim, E Sanli, L Brinkmann, M Lorenz, C N Gutt
• Journal: Surgical endoscopy (Surg Endosc) Vol. 16 Issue 9 Pg. 1292-6 (Sep 2002) ISSN: 1432-2218 [Electronic] Germany
• PMID: 12023723 (Publication Type: Journal Article)

Chemical References

• Dopamine Antagonists
• Endothelin-1
• Carbon Dioxide

Topics

• Animals
• Blood Flow Velocity (drug effects)
• Carbon Dioxide (adverse effects, therapeutic use)
• Chemotherapy, Cancer, Regional Perfusion (methods)
• Disease Models, Animal
• Dopamine Antagonists (pharmacology, therapeutic use)
• Endothelin-1 (antagonists & inhibitors, pharmacology, therapeutic use)
• Insufflation (adverse effects)
• Intraoperative Complications (prevention & control)
• Ischemia (prevention & control)
• Laparoscopy (adverse effects, methods)
• Liver (blood supply, drug effects, surgery)
• Male
• Microcirculation (drug effects)
• Pneumoperitoneum, Artificial (adverse effects, methods)
• Portal Vein (drug effects, surgery)
• Rats
• Rats, Inbred Strains
• Regional Blood Flow (drug effects)
• Ultrasonography, Doppler (methods)