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In vivo effect of the lipido-sterolic extract of Serenoa repens (Permixon) on mast cell accumulation and glandular epithelium trophism in the rat prostate.

Abstract
The Serenoa repens lipido-sterolic extract (SRLSE, Permixon, Pierre Fabre Medicament, Castres, France) is used to treat benign prostate hyperplasia. We studied the in vivo effect of SRLSE on mast cell accumulation and the histological characteristics of the rat ventral prostate. Adult Wistar rats received either tocopherol or SRLSE (50 and 100 mg/kg body weight, respectively) every second day for 90 days. Histological features were studied in hematoxylin-eosin stained tissue sections while mean mast cell numbers were determined in Giemsa-stained sections. The central region of the ventral prostate in treated animals showed significant changes with acinar epithelium becoming flat or low cuboidal. In the same region, mean mast cell number per optical field in the control, low-dose and high-dose groups were, respectively, 4.7+/-0.7, 3.4+/-1.0 and 2.4+/-0.6, showing a dose-dependent, statistically significant decrease. Administering SRLSE significantly reduces mast cell accumulation and provokes epithelium atrophy within the central area of the rat ventral prostate. These phenomena may participate in the clinical activity of the drug.
AuthorsDionisios Mitropoulos, Aspasia Kyroudi, Anastasios Zervas, Stefanos Papadoukakis, Aris Giannopoulos, Christos Kittas, Panagiotis Karayannacos
JournalWorld journal of urology (World J Urol) Vol. 19 Issue 6 Pg. 457-61 (Apr 2002) ISSN: 0724-4983 [Print] Germany
PMID12022715 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Androgen Antagonists
  • Plant Extracts
  • saw palmetto extract
  • Tocopherols
Topics
  • Androgen Antagonists (pharmacology)
  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Epithelium (drug effects, pathology)
  • Immunohistochemistry
  • Male
  • Mast Cells (drug effects)
  • Plant Extracts (pharmacology)
  • Prostate (drug effects, pathology)
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Reference Values
  • Sensitivity and Specificity
  • Serenoa
  • Tocopherols (pharmacology)

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