Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats.

Abstract

RATIONALE AND OBJECTIVES:

The neurotrophic effect of Xaliproden has been followed using sequential cerebral magnetic resonance imaging (MRI) in rats with vincristine-induced brain lesion as a model of Alzheimer disease.

METHODS:

Nineteen rats received an intraseptal injection of vincristine on day 0, followed by a daily gavage with either the vehicle (Tween-20 1%) (n = 10) or Xaliproden (10 mg/kg) (n = 9). Eight sham-operated controls received a daily gavage with either the vehicle (n = 4) or Xaliproden (n = 4). Brain MR imaging was performed at 4.7 T on a Biospec 47/30 MR system before surgery then 3, 7, 10, and 14 days after surgery.

RESULTS:

At day 3 following vincristine injection, an increase in MR signal intensity in the septum was observed on T2-weighted images. This increase was maximal at day 10, and remained stable until day 14. Daily treatment with Xaliproden delayed the appearance of hypersignals until day 7 and reduced by Ca. 50% the magnitude of the increase in signal intensity from day 10. No changes were observed in the hippocampus.

CONCLUSION:

Quantitative MRI objectifies noninvasively the neuroprotective effect of Xaliproden on rat brain anatomy.

• Authors: Laurent Lemaire, Jacqueline Fournier, Christian Ponthus, Yann Le Fur, Sylvaine Confort-Gouny, Jean Vion-Dury, Peter Keane, Patrick J Cozzone
• Journal: Investigative radiology (Invest Radiol) Vol. 37 Issue 6 Pg. 321-7 (Jun 2002) ISSN: 0020-9996 [Print] United States
• PMID: 12021588 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• Naphthalenes
• Neuroprotective Agents
• Pyridines
• Vincristine
• Choline O-Acetyltransferase
• xaliproden

Topics

• Alzheimer Disease (chemically induced, drug therapy, pathology)
• Animals
• Brain (drug effects, pathology)
• Choline O-Acetyltransferase (analysis, antagonists & inhibitors)
• Disease Models, Animal
• Enzyme Inhibitors
• Magnetic Resonance Imaging
• Male
• Naphthalenes (pharmacology, therapeutic use)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Pyridines (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Time Factors
• Vincristine